AustralieFrV1, Main, Exploration, bibRecord, 00C828

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

Identifieur interne : 00C828 ( Main/Exploration ); précédent : 00C827; suivant : 00C829

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

Auteurs : O. Wittekindt [Allemagne] ; S. G. Schwab [Allemagne] ; E. Burgert [Allemagne] ; M. Knapp [Allemagne] ; M. Albus [Allemagne] ; B. Lerer [Israël] ; J. Hallmayer [Australie] ; M. Rietschel [Allemagne] ; R. Segman [Allemagne] ; M. Borrmann [Allemagne] ; D. Lichtermann [Allemagne] ; M.-A. Crocq [France] ; W. Maier [Allemagne] ; D. J. Morris-Rosendahl [Allemagne] ; D. B. Wildenauer [Allemagne]

Source :

Molecular psychiatry [ 1359-4184 ] ; 1999.

RBID : Pascal:99-0339180

Descripteurs français

Pascal (Inist)
- Schizophrénie, Etude familiale, Déterminisme génétique, DNA microsatellite, Séquence répétée, Trinucléotide, Facteur risque, Génétique, Homme, Gène KCA3.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Family study, Genetic determinism, Genetics, Human, Microsatellite DNA, Repeated sequence, Risk factor, Schizophrenia, Trinucleotide.

Abstract

A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al¹ using a case-control design with patients with schizophrenia (n = 141) and matched controls (n = 158). The gene may be considered as an excellent candidate gene for psychiatric disorders, since it plays a role in modulating neuronal firing patterns by regulating the slow component of afterhyperpolarisation. In addition, the gene contains a highly polymorphic trinucleotide sequence (CAG) within exon 1, which encodes a polyglutamine stretch. The possible contribution of unstable trinucleotide repeats to the development of psychiatric disorders has previously been discussed.^2-4 Chandy et al¹ reported an over-representation of alleles with higher repeat number in schizophrenics as compared to controls (P= 0.0035). In an attempt to replicate these findings, we have performed a family-based study with 193 offspring/parent combinations using a sample of 49 multiplex families (two or more affected siblings with parents) and a second sample of 83 simplex families (one affected offspring with parents). No evidence for the association of longer repeats with schizophrenia was obtained when each sample was tested separately or when both samples were combined and tested for transmission disequilibrium.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 006325
to stream PascalFrancis, to step Curation: 006D29
to stream PascalFrancis, to step Checkpoint: 006140
to stream Main, to step Merge: 00D853
to stream Main, to step Curation: 00C828

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios</title>
<author><name sortKey="Wittekindt, O" sort="Wittekindt, O" uniqKey="Wittekindt O" first="O." last="Wittekindt">O. Wittekindt</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Fakultät for Biologie, Universität Freiburg, Schänzelstr 1</s1>
<s2>79104 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burgert, E" sort="Burgert, E" uniqKey="Burgert E" first="E." last="Burgert">E. Burgert</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knapp, M" sort="Knapp, M" uniqKey="Knapp M" first="M." last="Knapp">M. Knapp</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Statistics, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1>
<s2>91120 Jerusalem</s2>
<s3>ISR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>91120 Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hallmayer, J" sort="Hallmayer, J" uniqKey="Hallmayer J" first="J." last="Hallmayer">J. Hallmayer</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Graylands Hospital/University of Western Australia, Centre for Clinical Research in Neuropsychiatry</s1>
<s2>Mt Claremont, WA 6010</s2>
<s3>AUS</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Mt Claremont, WA 6010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M." last="Rietschel">M. Rietschel</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Segman, R" sort="Segman, R" uniqKey="Segman R" first="R." last="Segman">R. Segman</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Borrmann, M" sort="Borrmann, M" uniqKey="Borrmann M" first="M." last="Borrmann">M. Borrmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lichtermann, D" sort="Lichtermann, D" uniqKey="Lichtermann D" first="D." last="Lichtermann">D. Lichtermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crocq, M A" sort="Crocq, M A" uniqKey="Crocq M" first="M.-A." last="Crocq">M.-A. Crocq</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>FORENAP, Centre Hospitalier</s1>
<s2>68250 Rouffach</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Rouffach</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris Rosendahl, D J" sort="Morris Rosendahl, D J" uniqKey="Morris Rosendahl D" first="D. J." last="Morris-Rosendahl">D. J. Morris-Rosendahl</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0339180</idno>
<date when="1999">1999</date>
<idno type="stanalyst">PASCAL 99-0339180 INIST</idno>
<idno type="RBID">Pascal:99-0339180</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">006325</idno>
<idno type="wicri:Area/PascalFrancis/Curation">006D29</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">006140</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">006140</idno>
<idno type="wicri:doubleKey">1359-4184:1999:Wittekindt O:association:between:hskca</idno>
<idno type="wicri:Area/Main/Merge">00D853</idno>
<idno type="wicri:Area/Main/Curation">00C828</idno>
<idno type="wicri:Area/Main/Exploration">00C828</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios</title>
<author><name sortKey="Wittekindt, O" sort="Wittekindt, O" uniqKey="Wittekindt O" first="O." last="Wittekindt">O. Wittekindt</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Fakultät for Biologie, Universität Freiburg, Schänzelstr 1</s1>
<s2>79104 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burgert, E" sort="Burgert, E" uniqKey="Burgert E" first="E." last="Burgert">E. Burgert</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knapp, M" sort="Knapp, M" uniqKey="Knapp M" first="M." last="Knapp">M. Knapp</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Statistics, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1>
<s2>91120 Jerusalem</s2>
<s3>ISR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Israël</country>
<wicri:noRegion>91120 Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hallmayer, J" sort="Hallmayer, J" uniqKey="Hallmayer J" first="J." last="Hallmayer">J. Hallmayer</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Graylands Hospital/University of Western Australia, Centre for Clinical Research in Neuropsychiatry</s1>
<s2>Mt Claremont, WA 6010</s2>
<s3>AUS</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Mt Claremont, WA 6010</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M." last="Rietschel">M. Rietschel</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Segman, R" sort="Segman, R" uniqKey="Segman R" first="R." last="Segman">R. Segman</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Borrmann, M" sort="Borrmann, M" uniqKey="Borrmann M" first="M." last="Borrmann">M. Borrmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Mental State Hospital</s1>
<s2>85529 Haar</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>85529 Haar</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
<wicri:noRegion>Mental State Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lichtermann, D" sort="Lichtermann, D" uniqKey="Lichtermann D" first="D." last="Lichtermann">D. Lichtermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crocq, M A" sort="Crocq, M A" uniqKey="Crocq M" first="M.-A." last="Crocq">M.-A. Crocq</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>FORENAP, Centre Hospitalier</s1>
<s2>68250 Rouffach</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>68250 Rouffach</wicri:noRegion>
<wicri:noRegion>Centre Hospitalier</wicri:noRegion>
<wicri:noRegion>68250 Rouffach</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris Rosendahl, D J" sort="Morris Rosendahl, D J" uniqKey="Morris Rosendahl D" first="D. J." last="Morris-Rosendahl">D. J. Morris-Rosendahl</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut für Humangenetik und Anthropologie, Universität Freiburg</s1>
<s2>79106 Freiburg</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Bonn</s1>
<s2>53105 Bonn</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Molecular psychiatry</title>
<title level="j" type="abbreviated">Mol. psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Molecular psychiatry</title>
<title level="j" type="abbreviated">Mol. psychiatry</title>
<idno type="ISSN">1359-4184</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Family study</term>
<term>Genetic determinism</term>
<term>Genetics</term>
<term>Human</term>
<term>Microsatellite DNA</term>
<term>Repeated sequence</term>
<term>Risk factor</term>
<term>Schizophrenia</term>
<term>Trinucleotide</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Schizophrénie</term>
<term>Etude familiale</term>
<term>Déterminisme génétique</term>
<term>DNA microsatellite</term>
<term>Séquence répétée</term>
<term>Trinucléotide</term>
<term>Facteur risque</term>
<term>Génétique</term>
<term>Homme</term>
<term>Gène KCA3</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al<sup>1</sup>
 using a case-control design with patients with schizophrenia (n = 141) and matched controls (n = 158). The gene may be considered as an excellent candidate gene for psychiatric disorders, since it plays a role in modulating neuronal firing patterns by regulating the slow component of afterhyperpolarisation. In addition, the gene contains a highly polymorphic trinucleotide sequence (CAG) within exon 1, which encodes a polyglutamine stretch. The possible contribution of unstable trinucleotide repeats to the development of psychiatric disorders has previously been discussed.<sup>2-4</sup>
 Chandy et al<sup>1</sup>
 reported an over-representation of alleles with higher repeat number in schizophrenics as compared to controls (P= 0.0035). In an attempt to replicate these findings, we have performed a family-based study with 193 offspring/parent combinations using a sample of 49 multiplex families (two or more affected siblings with parents) and a second sample of 83 simplex families (one affected offspring with parents). No evidence for the association of longer repeats with schizophrenia was obtained when each sample was tested separately or when both samples were combined and tested for transmission disequilibrium.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Israël</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Cologne</li>
<li>District de Fribourg-en-Brisgau</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bonn</li>
<li>Fribourg-en-Brisgau</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Wittekindt, O" sort="Wittekindt, O" uniqKey="Wittekindt O" first="O." last="Wittekindt">O. Wittekindt</name>
</region>
<name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name>
<name sortKey="Borrmann, M" sort="Borrmann, M" uniqKey="Borrmann M" first="M." last="Borrmann">M. Borrmann</name>
<name sortKey="Burgert, E" sort="Burgert, E" uniqKey="Burgert E" first="E." last="Burgert">E. Burgert</name>
<name sortKey="Knapp, M" sort="Knapp, M" uniqKey="Knapp M" first="M." last="Knapp">M. Knapp</name>
<name sortKey="Lichtermann, D" sort="Lichtermann, D" uniqKey="Lichtermann D" first="D." last="Lichtermann">D. Lichtermann</name>
<name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name>
<name sortKey="Morris Rosendahl, D J" sort="Morris Rosendahl, D J" uniqKey="Morris Rosendahl D" first="D. J." last="Morris-Rosendahl">D. J. Morris-Rosendahl</name>
<name sortKey="Rietschel, M" sort="Rietschel, M" uniqKey="Rietschel M" first="M." last="Rietschel">M. Rietschel</name>
<name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name>
<name sortKey="Segman, R" sort="Segman, R" uniqKey="Segman R" first="R." last="Segman">R. Segman</name>
<name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name>
<name sortKey="Wittekindt, O" sort="Wittekindt, O" uniqKey="Wittekindt O" first="O." last="Wittekindt">O. Wittekindt</name>
</country>
<country name="Israël"><noRegion><name sortKey="Lerer, B" sort="Lerer, B" uniqKey="Lerer B" first="B." last="Lerer">B. Lerer</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Hallmayer, J" sort="Hallmayer, J" uniqKey="Hallmayer J" first="J." last="Hallmayer">J. Hallmayer</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Crocq, M A" sort="Crocq, M A" uniqKey="Crocq M" first="M.-A." last="Crocq">M.-A. Crocq</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C828 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00C828 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:99-0339180
   |texte=   Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri